Basic information:

Untranslated mRNA: Regulatory mRNA

Related IDs	cncRNA ID	CNC_M_001435
	Name	VCL
	Gene ID	7414
Location	Coordinate(Strand)	10:73995193-74121363(+)
Locus Sequence
Organism	Homo sapiens

Evidence support:

  

In vivo/vitro assay	In vitro assay
Low-throughput method	Gel mobility shift assay;PKR activation assay;In vitro translation assay
High-throughput method	/
Tissue/Cell	/
Description of experimental evidence	The mRNA was detected by Gel mobility shift assay, PKR activation assay and in vitro translation assay, which can inhibit translation by activate PKR.

Orthologues:

  

Chimpanzee	ENSPTRG00000002647
Mouse	ENSMUSG00000021823
Drosophila	FBgn0004397
Zebrafish	ENSDARG00000098695   ENSDARG00000044968

References:

  

PMID	11861913
Description	We show that the 3'-UTRs of the cytoskeletal mRNAs interact with the RNA-binding domain of the RNA-activated protein kinase PKR. Correspondingly, these RNAs activate PKR in vitro and inhibit globin translation in the rabbit reticulocyte lysate translation system.

Related Subcelluar Localization:

  

Subcelluar Localization	RLID	Link to RNALocate
Nucleus	RLID00040527	Link to RNALocate
chromatin	RLID00102859	Link to RNALocate
cytosol	RLID00102860	Link to RNALocate
insoluble cytoplasm	RLID00102861	Link to RNALocate
nucleolus	RLID00102862	Link to RNALocate
nucleoplasm	RLID00102863	Link to RNALocate
nucleus	RLID00102864	Link to RNALocate
nucleus	RLID00102865	Link to RNALocate
exosome	RLID00102866	Link to RNALocate
Nucleus	RLID00021493	Link to RNALocate
Ribosome	RLID00021494	Link to RNALocate
Cytosol	RLID00021495	Link to RNALocate

Related Diseases:

  

OMIM Phenotype	Phenotype MIM number	Link to OMIM
Cardiomyopathy, dilated, 1W	OMIM:611407	Link to OMIM
Cardiomyopathy, hypertrophic, 15	OMIM:613255	Link to OMIM

Related Interactions:

  

  

   Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).