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Detail Information
Basic information:
Untranslated mRNA: Regulatory mRNA
| Related IDs | cncRNA ID | CNC_M_001434 | |
|---|---|---|---|
| Name | TNNI1 | ||
| Gene ID | 7135 | ||
| Location | Coordinate(Strand) | 1:201403768-201429866(-) | |
| Locus Sequence | |||
| Organism | Homo sapiens | ||
Evidence support:
| In vivo/vitro assay | In vitro assay | |
|---|---|---|
| Low-throughput method | Gel mobility shift assay;PKR activation assay;In vitro translation assay | |
| High-throughput method | / | |
| Tissue/Cell | / | |
| Description of experimental evidence | The mRNA was detected by Gel mobility shift assay, PKR activation assay and in vitro translation assay, which can inhibit translation by activate PKR. | |
Orthologues:
| Chimpanzee | ENSPTRG00000001834 |
|---|---|
| Mouse | ENSMUSG00000026418 |
| Drosophila | FBgn0283471 |
| Zebrafish | ENSDARG00000000474 ENSDARG00000052708 |
References:
| PMID | 11861913 |
|---|---|
| Description | We show that the 3'-UTRs of the cytoskeletal mRNAs interact with the RNA-binding domain of the RNA-activated protein kinase PKR. Correspondingly, these RNAs activate PKR in vitro and inhibit globin translation in the rabbit reticulocyte lysate translation system. |