Basic information:

Untranslated mRNA: Regulatory mRNA

Related IDs	cncRNA ID	CNC_M_001429
	Name	SRA1
	Gene ID	10011
Location	Coordinate(Strand)	5:140537340-140558252(-)
Locus Sequence
Organism	Homo sapiens

Evidence support:

  

In vivo/vitro assay	In vitro assay
Low-throughput method	Transfection assay;Northern blotting;RT-PCR
High-throughput method	/
Tissue/Cell	Hela cell
Description of experimental evidence	The mRNA was detected by transfection and northern blotting in Hela cell, which function as a transcriptional coactivator.

Orthologues:

  

Chimpanzee	ENSPTRG00000017314
Mouse	ENSMUSG00000006050
Drosophila	/
Zebrafish	ENSDARG00000053619

References:

  

PMID

10199399

Description

We report the isolation and functional characterization of a novel transcriptional coactivator, termed steroid receptor RNA activator (SRA). SRA is selective for steroid hormone receptors and mediates transactivation via their amino-terminal activation function. We provide functional and mechanistic evidence that SRA acts as an RNA transcript. We suggest that SRA may act to confer functional specificity upon multiprotein complexes recruited by liganded receptors during transcriptional activation.

Related Subcelluar Localization:

  

Subcelluar Localization	RLID	Link to RNALocate
chromatin	RLID00048465	Link to RNALocate
cytosol	RLID00048466	Link to RNALocate
nucleolus	RLID00048467	Link to RNALocate
nucleoplasm	RLID00048468	Link to RNALocate
nucleus	RLID00048469	Link to RNALocate
exosome	RLID00048470	Link to RNALocate
Ribosome	RLID00000095	Link to RNALocate

Related Interactions:

  

  

   Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).