Basic information:

Untranslated mRNA: Regulatory mRNA

Related IDs	cncRNA ID	CNC_M_001422
	Name	PHB
	Gene ID	5245
Location	Coordinate(Strand)	17:49404049-49414905(-)
Locus Sequence
Organism	Homo sapiens

Evidence support:

  

In vivo/vitro assay	In vitro assay and in vivo assay (Mouse)
Low-throughput method	Transfection assay;Cell proliferation assay;In vitro tumorigenicity assay
High-throughput method	/
Tissue/Cell	MCF7 cell
Description of experimental evidence	The mRNA was detected by transfection and cell proliferation assay in MCF7 cell, which can casuse cell cycle arrest.

Orthologues:

  

Chimpanzee	ENSPTRG00000047126
Mouse	/
Drosophila	FBgn0002031
Zebrafish	ENSDARG00000057414

References:

  

PMID	14500355
Description	In the present study, we examined the tumor suppressor activity of the prohibitin 3'UTR in human breast cancer cells. Stable clones of MCF7 cells expressing either the C allele or the T allele RNA under the control of the cytomegalovirus promoter were isolated and compared with empty vector clones.

Related Subcelluar Localization:

  

Subcelluar Localization	RLID	Link to RNALocate
chromatin	RLID00085584	Link to RNALocate
nucleus	RLID00085585	Link to RNALocate
nucleus	RLID00085586	Link to RNALocate
exosome	RLID00085587	Link to RNALocate
Ribosome	RLID00015041	Link to RNALocate
Endoplasmic reticulum	RLID00015042	Link to RNALocate

Related Diseases:

  

OMIM Phenotype	Phenotype MIM number	Link to OMIM
Breast cancer, susceptibility to	OMIM:114480	Link to OMIM

Related Interactions:

  

  

   Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).