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Detail Information


Basic information:


Untranslated mRNA: Regulatory mRNA

Related IDs cncRNA ID CNC_M_001421
Name P53
Gene ID 7157
Location Coordinate(Strand) 17:7661779-7687550(-)
Locus Sequence
Organism Homo sapiens

Evidence support:

  
In vivo/vitro assay In vitro assay
Low-throughput method RNA co-immunoprecipitation;RNA EMSA
High-throughput method /
Tissue/Cell H1299 cell
Description of experimental evidence The mRNA was detected by RNA co-immunoprecipitation and RNA EMSA in H1299 cell, which can bind with Mdm2 to stimulate translation of the P53 mRNA.

Orthologues:

  
Chimpanzee ENSPTRG00000008703  
Mouse ENSMUSG00000059552  
Drosophila FBgn0039044  
Zebrafish ENSDARG00000035559  

References:

  
PMID 19160491
Description Here we show that the p53 mRNA region encoding the Mdm2-binding site interacts directly with the RING domain of Mdm2. This impairs the E3 ligase activity of Mdm2 and promotes p53 mRNA translation. We also show that introduction of cancer-derived single silent point-mutations in the p53 mRNA weakens its binding to Mdm2 and results in reduced p53 activity.

Related Diseases:

  
OMIM Phenotype Phenotype MIM number Link to OMIM
Breast cancer, somatic OMIM:114480 Link to OMIM
Hepatocellular carcinoma, somatic OMIM:114550 Link to OMIM
Li-Fraumeni syndrome OMIM:151623 Link to OMIM
Nasopharyngeal carcinoma, somatic OMIM:607107 Link to OMIM
Adrenocortical carcinoma, pediatric OMIM:202300 Link to OMIM
Osteosarcoma OMIM:259500 Link to OMIM
Pancreatic cancer, somatic OMIM:260350 Link to OMIM
Choroid plexus papilloma OMIM:260500 Link to OMIM
Basal cell carcinoma 7 OMIM:614740 Link to OMIM
Colorectal cancer OMIM:114500 Link to OMIM
Glioma susceptibility 1 OMIM:137800 Link to OMIM
Bone marrow failure syndrome 5 OMIM:618165 Link to OMIM