Basic information:

Untranslated mRNA: Regulatory mRNA

Related IDs	cncRNA ID	CNC_M_001410
	Name	DMPK
	Gene ID	1760
Location	Coordinate(Strand)	19:45769709-45782552(-)
Locus Sequence
Organism	Homo sapiens

Evidence support:

  

In vivo/vitro assay	In vitro assay
Low-throughput method	Photocrosslinking;Immunopurification;Western blotting
High-throughput method	/
Tissue/Cell	Hela cell
Description of experimental evidence	The mRNA was detected by photocrosslinking and immunopurification in Hela cell, which can bind to CUG-BP1 and CUG-BP2.

Orthologues:

  

Chimpanzee	ENSPTRG00000011166
Mouse	ENSMUSG00000030409
Drosophila	FBgn0267390   FBgn0052944
Zebrafish	/

References:

  

PMID	8948631
Description	We propose that the (CUG)n repeat region in Mt-PK mRNA is a binding site for CUG-BP/hNab50 in vivo, and triplet repeat expansion leads to sequestration of this hnRNP on mutant Mt-PK transcripts.

Related Subcelluar Localization:

  

Subcelluar Localization	RLID	Link to RNALocate
Nucleus	RLID00038545	Link to RNALocate
Cytoplasm	RLID00038546	Link to RNALocate
chromatin	RLID00062270	Link to RNALocate
cytosol	RLID00062271	Link to RNALocate
nucleolus	RLID00062272	Link to RNALocate
nucleoplasm	RLID00062273	Link to RNALocate
nucleus	RLID00062274	Link to RNALocate
exosome	RLID00062275	Link to RNALocate
Ribosome	RLID00004647	Link to RNALocate

Related Diseases:

  

OMIM Phenotype	Phenotype MIM number	Link to OMIM
Myotonic dystrophy 1	OMIM:160900	Link to OMIM

Related Interactions:

  

  

   Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).