Basic information:

Untranslated mRNA: Regulatory mRNA

Related IDs	cncRNA ID	CNC_M_001406
	Name	ACTN3
	Gene ID	89
Location	Coordinate(Strand)	11:66546395-66563334(+)
Locus Sequence
Organism	Homo sapiens

Evidence support:

  

In vivo/vitro assay	In vitro assay
Low-throughput method	Gel mobility shift assay;PKR activation assay;In vitro translation assay
High-throughput method	/
Tissue/Cell	/
Description of experimental evidence	The mRNA was detected by Gel mobility shift assay, PKR activation assay and in vitro translation assay, which can inhibit translation by activate PKR.

Orthologues:

  

Chimpanzee	ENSPTRG00000052354
Mouse	ENSMUSG00000006457
Drosophila	/
Zebrafish	ENSDARG00000001431   ENSDARG00000013755

References:

  

PMID	11861913
Description	We show that the 3'-UTRs of the cytoskeletal mRNAs interact with the RNA-binding domain of the RNA-activated protein kinase PKR. Correspondingly, these RNAs activate PKR in vitro and inhibit globin translation in the rabbit reticulocyte lysate translation system.

Related Subcelluar Localization:

  

Subcelluar Localization	RLID	Link to RNALocate
nucleus	RLID00112097	Link to RNALocate
exosome	RLID00112098	Link to RNALocate
Cytosol	RLID00025329	Link to RNALocate

Related Diseases:

  

OMIM Phenotype	Phenotype MIM number	Link to OMIM
Alpha-actinin-3 deficiency	OMIM:617749	Link to OMIM
Sprinting performance	OMIM:617749	Link to OMIM

Related Interactions:

  

  

   Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).