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Detail Information


Basic information:


Translated ncRNA: lncRNA

Related IDs cncRNA ID CNC_N_000148
Name Dworf
Gene ID ENSMUSG00000103476
Location Coordinate(Strand) 3:63481112-63483879(-)
Notes It has been re-annotated as protein coding gene now
Locus Sequence
Organism Mus musculus

Peptide information:

  
Peptide MAEKESTSPHLMVPILLLVGWIVGCIIVIYIVFF
Peptide length 34

Evidence support:

  
In vivo/vitro assay In vitro assay and in vivo assay (Mouse)
Low-throughput method Western blotting
High-throughput method /
Tissue/Cell Heart;Soleus
Description of experimental evidence The peptide was detected by western blotting in heart and soleus cell, which can enhances SERCA activity.

Orthologues:

  
Human /
Chimpanzee /
Drosophila /
Zebrafish /

References:

  
PMID 26816378
Description We discovered a putative muscle-specific long noncoding RNA that encodes a peptide of 34 amino acids and that we named dwarf open reading frame (DWORF).DWORF localizes to the SR membrane, where it enhances SERCA activity by displacing the SERCA inhibitors, phospholamban, sarcolipin, and myoregulin.