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Detail Information


Basic information:


Translated ncRNA: circRNA

Related IDs cncRNA ID CNC_N_000005
Name circ-NCX1
Gene ID ENSG00000183023
Location Coordinate(Strand) 2:40097270-40611053(-)
Locus Sequence
Organism Homo sapiens

Evidence support:

  
In vivo/vitro assay In vitro assay
Low-throughput method Western blotting;Oligonucleotide affinity chromatography;IPCR;RT-PCR
High-throughput method /
Tissue/Cell HEK-293 cell
Description of experimental evidence The peptide was detected by western blotting in HEK-293 cell, which which can regulate the Na/Ca exchange activity.

Orthologues:

  
Chimpanzee ENSPTRG00000011861  
Mouse ENSMUSG00000054640  
Drosophila /
Zebrafish ENSDARG00000043406  

References:

  
PMID 10075718
Description In the present report we demonstrate that the 1.8-kb message, which has a tissue and subcellular distribution matching that of full-length NCX1 but is not polyadenylated, corresponds to a perfectly circularized exon 2 species. The circular transcript contained the normal NCX1 start codon, a new stop codon introduced as a consequence of circularization, and encoded a protein corresponding to the NH2-terminal portion of NCX1, terminating just after amino acid 600 in the cytoplasmic loop.